How Great Brunello is Made. A Sangionvese clone dating back to the 19th century. Brunello, the signature wine of Tuscany's tiny commune of Montalcino, holds a special place in the hearts of Italian wine aficionados. Its broad structure and harmony of unusual aromas distinguishes it as a truly noble wine exempt from imitation. A top Brunello from a great vintage is truly a remarkable wine. The Biondi-Santi Brunello being the most notable.