'City of Bones' - the Mortal Instruments. the Iratze rune. (Heal/Hurt Not.) An Iratze is a Rune used by Shadowhunters to heal them of all non-demonic injuries. These runes glow golden when used before sinking into the skin, not even leaving a scar behind like average runes. Iratze Runes are placed closer to the heart for maximum effect and begin healing before completion.