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GPNMB: emerging therapeutic target in cancer

Abstract: Molecularly targeted therapies are rapidly growing with respect to their clinical development and impact on cancer treatment due to their highly selective anti-tumor action. However, many aggressive cancers such as triple-negative breast cancer (TNBC) currently lack well-defined therapeutic targets against which such agents can be developed. Read this review and sign up to receive OncoTargets and Therapy journal here: http://www.dovepress.com/articles.php?article_id=13605
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Figure 1 A schematic representation of GPNMB indicating the domains and motifs contributing to GPNMB function.

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Dove Medical Press

Figure 2 Potential mechanisms through which GPNMB promotes malignant cellular phenotypes within cancer cells.

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Dove Medical Press

Figure 3 Therapeutic strategies employing anti-GPNMB antibody-drug conjugates (ADCs).

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Dove Medical Press