Matteo Briguglio
Matteo Briguglio
Matteo Briguglio

Matteo Briguglio

Altre idee da Matteo

A Streptococcus Bacteria dividing by binary fission. SEM.

Fertilization. Coloured scanning electron micrograph (SEM) of a sperm (blue) attempting to penetrate a human egg (orange).

SEM image of blood clot

Ruptured capillary. Coloured scanning electron micrograph (SEM) of a red blood cell squeezing out of a torn capillary. A capillary is the smallest type of blood vessel, often only just large enough for red blood cells to pass through. Red blood cells (erythrocytes) are biconcave, disc-shaped cells that transport oxygen from the lungs to body cells. Credit: STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY

NUTRITION AND THE EPIGENOME. Great link to genetics info via the university of Utah.

Despite remarkable variation, all cells within the body are derived by from a single origin - the fertilised egg - and therefore contain identical DNA . Each cell type requires access to only a certain combination of genes to fulfil specific their job. It is critical that a cell activates (switches on) and maintains the correct gene programs while simultaneously silencing (switching off) unwanted genes. Epigenetic regulation of chromatin is central to this control of gene expression

Intermediates of energy metabolism are cofactors for chromatin modifications. The tricarboxylic acid (TCA) cycle links energy pathways with epigenetic chromatin modifications (blue). Metabolic cofactors for chromatin-modifying enzymes are shown in red. Several of these reactions directly associated with energy metabolism also occur in the cytoplasm. Furthermore, numerous epigenetic enzymes may compete for the same cofactor to modify distinct substrates.

Gene function is primarily regulated by chromatin accessibility. Methylated cytosine bases are recognised by methyl-binding proteins and remodeling factors to establish transcriptionally incompetent chromatin architectures. Modification of histone proteins further regulates transition between active and silent chromatin. Shown here is a summary of acetyl (green) and methyl (red) modifications of specific sites on N-terminal tails of the heavily modified H3 and H4 histones.